http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0645382-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5610690048edbc271e03b26b23f76ff9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 |
| filingDate | 1994-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdb490bc25432fb6658fcef41e52492c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbfe62c9beef1e84675e36ff47543f32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1afb261530e214a311eaf59e79549af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b87ff88ff3596629161c5e8e039782b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c173ed8d7d6f14c1c6adb0c7fdf7b82d |
| publicationDate | 1995-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0645382-A1 |
| titleOfInvention | Coumarin derivative and use thereof |
| abstract | The invention provides a compound having a 12-lipoxygenase inhibitory effect and a drug selectively inhibiting 12-lipoxygenase and relates to a novel coumarin derivative represented by general formula (1) and a drug comprising said compound as the active ingredient. In formula (1) R¹ represents hydrogen or lower alkyl; R² and R³ represent each hydrogen or hydroxyl provided that R² and R³ do not represent hydrogen atoms at the same time; and Ar represents (a) (b), (c) etc.; and R⁴ represents lower alkyl, lower alkoxy, halogen, trifluoromethyl or cyano. It further provides a compound which can be converted into another compound capable of selectively inhibiting 12-lipoxygenase activity through cleavage and breakage of its modifying moiety in vivo and a drug which selectively inhibits 12-lipoxygenase and relates to a novel coumarin derivative having an acyl group as the modifying moiety and a drug containing said compound as the active ingredient. The invention compound, which can potently inhibit 12-lipoxygenase at a high selectivity, is useful as a drug for preventing and treating circulatory diseases such as arteriosclerosis and vasoconstriction and preventing the metastasis of certain cancers. It has a low toxicity and little exhibits side effects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2543371-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0110881-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6372895-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9381187-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE46558-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6566508-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8475776-B2 |
| priorityDate | 1993-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 724.