| abstract |
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has structural formula (I), wherein R is a C-17 side chain, R1 is -OH, =O, or the like, R?8 and R9¿ are independently hydrogen or lower alkyl, and X and Y are N, N←O, CH, C-OH, C-OCH¿3? or C-Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds. |