| abstract |
The invention aims at providing a safe technique for remarkably improving the yield of an α,β-unsaturated ketone through introduction of an ω-chain into an aldehyde without being accompanied by the generation of hydrogen in the process for synthesizing a prostaglandin, in particular, one having at least one halogen atom in the 16- or 17-position. The invention process comprises conducting the reaction of an aldehyde with a 2-oxoalkylphosphonate in the presence of a base and a zinc compound. |