http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0641196-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71d6baf3c4e9a9bf1ef89d86cc77802e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate | 1993-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40fa3fc37fd8e7bc715b6b5161de35de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1f79fc0038a98d05958b04b18efdeb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b3b3d24c10215820e38391a39bbd8f0 |
| publicationDate | 1995-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0641196-A1 |
| titleOfInvention | Microencapsulation of cells |
| abstract | PCT No. PCT/US93/05122 Sec. 371 Date Dec. 23, 1994 Sec. 102(e) Date Dec. 23, 1994 PCT Filed May 28, 1993 PCT Pub. No. WO93/24112 PCT Pub. Date Dec. 9, 1993In accordance with the present invention, it has been discovered that a major reason for the failure to achieve successful in vivo transplantation in large mammalian species has been flaws associated with the design of microcapsules taught in the prior art, flaws in the method of making such microcapsules, and a lack of tests to determine if a given microcapsule will be successful. In accordance with the present invention, a number of functional properties which must be met by a microcapsule in order to achieve successful in vivo transplantation in large animal models have been identified. These properties include (i) a mechanically stable capsule core, (ii) a mechanically strong capsule membrane (i.e., the membrane must be of sufficient strength to prevent capsule disruption), (iii) the absence of excess exposed positively-charged PLL (which leads to fibrosis), and (iv) an adequate level of diffusion of the entrapped biologically active material out of the capsule. |
| priorityDate | 1992-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.