| abstract |
A sustained release pharmaceutical composition for oral administration having a core comprising (a) 1,3-dimethyl-6-{2-{N-(2-hydroxyethyl)-N-[3-(4-nitrophenyl) propyl]amino}ethylamino}-2,4-(1H,3H)-pyrimidinedione or its acid adduct as an active component, (b) an organic acid, and (c) a water soluble polymer such as polyvinyl alcohol, anda coat comprising a mixture of (d) a water insoluble polymer and (e) a water soluble polymer, the components (a) to (c) being permeable together through the coat so that the active component (a) may be stably dissolved in an intestinal liquid and may not precipitate in a short period of time. |