| abstract |
Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer. |