| abstract |
Peptide T and its linear or cyclic analogues of the General Formula 1: I-A-B-C-D-E-F-G-H-II wherein A is Ala, Gly, Val, Ser, Thr or absent; B is Ala, Gly, Val, Ser, Thr or absent; C is Ser, Thr or absent; D is Ser, Thr, Asn, Glu, Arg, Ile, Leu or absent; E is Ser, Thr, Asp or absent; F is Thr, Ser, Asn, Arg, Gln, Lys, Trp or absent; G is Tyr or absent; H is Thr, Arg, Gly, Met, Met(O), Cys, Thr, Gly or absent; and I is Cys or absent; II is Cys, an amide group, substituted amide group, an ester group or absent; at least one of the amino acids optionally being substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino and/or amido groups of the amino acids, comprising at least 4 amino acids, and their pharmaceutically acceptable salts, are useful in the treatment or prevention of inflammation. In particular, the peptides are useful in the treatment or prevention of multiple sclerosis, myelopathies (including HTLV-1 associate myelopathy) and symptoms and diseases associated with chronic immune activation, including chronic fatigue syndrome, toxic shock, arthritis, inflammatory bowel disease and host-versus-graft and graft-versus-host responses in transplant recipients. |