| abstract |
PCT No. PCT/GB93/00273 Sec. 371 Date Oct. 27, 1994 Sec. 102(e) Date Oct. 27, 1994 PCT Filed Feb. 10, 1993 PCT Pub. No. WO93/16075 PCT Pub. Date Aug. 19, 1993.The present invention is directed to compounds of general formula I as well their pharmaceutically and veterinarily acceptable acid addition salts or hydrates thereof. The present invention is further directed to pharmaceutical and veterinary compositions containing the compounds of general formula I. The present compounds of general formula I are antagonist of platelet activating factor (PAF). Accordingly, the present invention is also directed to methods for preventing, treating or ameliorating in human or mammalian animals, various diseases or physiological conditions mediated by PAF. |