| abstract |
A quinoline-3-acetic acid derivative represented by general formula (I) or a medicinally acceptable salt thereof, wherein R¹, R² and R³ may be the same or different from one another and each represents hydrogen or halogen; R⁴ represents hydrogen, halogen or (un)substituted lower alkyl: R⁵ represents optionally esterified carboxyl; and the broken line represents an optional presence of a double bond. The compound (I) and the salt have an aldose reductase inhibitor activity against mammals including man and are excellent in safety, and hence are useful as the drug for the therapeutic treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis. |