| abstract |
A novel anti-active-oxygen agent which inhibits the generation of active oxygen species, is highly safe, can be preparated at a rather low cost, and contains an amino acid derivative represented by general formula (I) or a salt thereof as the active ingredient, wherein Ar represents 2-hydroxyphenyl, 2-hdyroxyl-1-naphthyl or pyridyl provided that the aromatic rings of these groups may be substituted by halogen, alkyl, hydroxy, hydroxyalkyl, nitro, alkoxy or carboxy; R represents the side chain of an amino acid; X represents -CH₂-NH- or -CH=N-; Y represents hydrogen, -COOR¹, -SO₃H, -CON(R²)R³, -CONHCH(R⁵)COOR⁴ or -CH₂OH, wherein R¹ to R⁴ represent each hydrogen or alkyl, and R⁵ represents the side chain of an amino acid; and n represents an integer of 0 or 1. |