| abstract |
The present invention relates to compounds and compositions and methods for the treatment of pain, and derivatives thereof which have potent analgesic activity. The compounds have the formula (I) in which R1 is selected from H, lower alkyl, C3-C9 cycloalkyl, acyl, and C3-C9 cycloalkylalkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, or C3-C8 cycloalkenyl or C3-C8 cycloalkynyl ; and wherein R is selected from cycloalkyl, aryl, heteroaryl (selected from the group consisting of pyrridyl, thienyl, furanyl, imidazolyl, pyrazinyl and pyrimidyl) or phenoxy; the groups of said R can be substituted with hydroxyl, C1-C6 lower alkyl, C2-C6 alkenyl, C1-C6 lower alkoxyl, halo, C1-C6 haloalkyl, amino, C1-C6 alkylamino and C2-C10 dialkylamino, and sulfonamido or a pharmaceutically acceptable salt thereof. |