| abstract |
Disclosed are biphenylmethane derivatives having the formula: <CHEM> wherein R<2> and R<3>, which may be the same or different, are each a hydrogen atom, a halogen atom, a lower C1-6 alkyl group a lower C1-6 alkoxy group, a carbamoyl group or a cyano group; R<4> stands for hydrogen or a lower C1-6 alkyl group; R<5> is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof; R<6> stands for hydrogen, a halogen atom, a hydroxy group or a lower C1-6 alkoxy group, or a pharmacologically acceptable salt thereof, wherein compounds having the following formula and their pharmacologically acceptable salts are excluded: <CHEM> wherein R<5> is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof and n is an integer of 1 to 2; or a pharmacologically acceptable salt thereof. Further, a process for their preparation, pharmaceutical compositions containing same and their use for the preparation of such compositions for preventing and treating hypertension and/or cardiac failure are disclosed. |