| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5c450bfedfc111b05db4c1419c3c70a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 |
| filingDate |
1993-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_694322aae3c6654bbafb509d33acfd6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_148d42eefd424f82eb9d031325cc9040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c905b6eb34f017dddc1480dd1530867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_589cb6f1335faea9c3d3e0b3a65cabba |
| publicationDate |
1994-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0626381-A1 |
| titleOfInvention |
Preparation of form 1 ranitidine hydrochloride |
| abstract |
Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1 - 2.0 parts by volume of a Cā - Cāā aromatic hydrocarbon such as toluene, and in the presence of seed crystals of pure Form 1 ranitidine hydrochloride. In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2942058-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0859768-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2929884-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015155297-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0859768-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5621120-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9619232-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0694540-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6855835-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6815548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0164662-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015169957-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1394160-A1 |
| priorityDate |
1993-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |