| abstract |
A lowly toxic and excellent inhibitor for restenosis after percutaneous coronary arterioplasty containing as the active ingredient a compound represented by general formula (1) or (1') or a physiologically acceptable salt thereof, wherein R¹ and R² represent each independently hydrogen, halogen, trifluoromethyl, nitro, C₁₋C₆ alkyl or C₁₋C₆ alkoxy, or alternatively R¹ and R² are combined together to form methylenedioxy; R³ represents aryl, aromatic heterocycle, 5-to 7-membered cycloalkyl or 5- to 7-membered cycloalkenyl each of which may be substituted; R⁴ represents hydrogen, hydroxy, - S-glutathionyl, -S-(α-amino acyl) or aralkyl wherein the aryl group may be substituted; R⁵ represents hydrogen or C₁-C₆ alkyl, or alternatively R⁴ and R⁵ are combined together to form a single bond; Y represents oxygen or sulfur; n represents an integer of 0 to 5; and the selenium atom may be oxidized. |