http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0619315-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e05ecc55c1afdb18fa200bbf0bb4c642 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-655372 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D335-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-382 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-12 |
| filingDate | 1994-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c3c308477c0ae0a8b6728130ea850e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e234d2b106f50b952d03df7c10937c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5e122ebb6c34a644e30ef8124916b3c |
| publicationDate | 1994-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0619315-A1 |
| titleOfInvention | Thioxanthenone antitumor agents |
| abstract | Compounds having anti-tumour activity are disclosed having the formulan n wherein:n (1) n is 2 or 3;n R¹ and R² are independently lower-alkyl; Q is a residue chosen from the group consisting of CH₂NHR³, CH₂N(R⁴)SO₂R⁷, CH₂NHCHO, CH=N-Ar, C(O)NR⁵R⁶, CH₂N(R⁴)C(O)R⁷, CH₂N(C₂H₅)CHO, CH₂N(R⁴)P(O)(O-lower-alkyl)₂ , CH₂N=CH-N(R⁹)(R¹⁰), CH₂N(R⁴)C(O)CF₃ and CH₂N(R⁴)C(O)OR⁷; R³ is hydrogen or lower-alkyl; R⁴ is hydrogen, lower-alkyl or Ar; R⁵ is hydrogen, lower-alkyl or Ar; R⁶ is hydrogen or lower-alkyl; R⁷ is lower-alkyl, or Ar; R⁸ is hydroxy; Ar is phenyl or phenyl substituted with methyl, methoxy, hydroxy, halogen or nitro; and R⁹ and R¹⁰ are independently lower-alkyl; or (2) Q is a residue chosen from the group consisting of CH₂N(R⁴)SO₂R⁷, CH=N-Ar, C(O)NR⁵R⁶, CH₂N(R⁴)C(O)R⁷, CH₂N(R⁴)P(O)(O-lower-alkyl)₂, CH₂N(R⁴)C(O)CF₃ and CH₂N(R⁴)C(O)OR⁷; R⁸ is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; Ar is phenyl substituted by hydroxy; and n, R¹, R², R⁴, R⁵, R⁶, and R⁷ are as defined hereinabove in part (1) with the proviso that one or more of R⁴, R⁵, or R⁷ is Ar; or (3) Q is a residue chosen from the group consisting of CH₂N=CH-N(R⁹)(R¹⁰), CH₂N(R⁴)C(O)CF₃ and CH₂N(R⁴)C(O)OR⁷; R⁸ is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; and n, R¹, R², R⁴, R⁷, Ar, R⁹ and R¹⁰ are as defined hereinabove in part (1), or a pharmaceutically acceptable acid-addition salt or solvate thereof. n Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9710809-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-716782-B2 |
| priorityDate | 1993-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 480.