abstract |
Selectivity by pH regulation of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexa-azacyclomacrocycles having specified structures of pendant side chain chelating groups. The mono and diacetic acid derivatives prepared, with the monomethylenephosphonate and monomethylenephosphinate derivatives of [12] aneN4, [12] aneN3 and [9] aneN3, make these types of ligands readily available by a synthetic route which avoids the use of groups protectors. The invention thus includes a variety of compounds, methods and uses characterized by a relatively high synthetic yield of polyazamacrocyclic ligands having a wide and predictable choice of constants of bonding of metal ions and of lipid and aqueous solubilities due to their pendant substitution groups. |