| abstract |
The compounds described have the formula (I) in which Y represents a halogen atom or a group -OR1, in which R1 represents an optionally substituted alkyl group; R2 represents an optionally substituted cycloalkyl or cycloalkenyl group; R3 represents a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, nitrogen or sulfide atoms or a group -N (R4) - in which R4 represents a hydrogen atom or an alkyl group ; X represents -O-, -S-, or -N (R5) -, wherein R5 represents a hydrogen atom or an alkyl group; with the proviso that when X represents -O-, R3 is not a 3-cyanomino-6-pyridazinyl group or a 3-chloro-6-pyridazinyl. The invention also relates to the salts, solvates, hydrates and N-oxides of these compounds. The compounds are selective phosphodiesterase inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases. |