Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3120ae9cab5bb4831f0cc16288966367 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
filingDate |
1992-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a7a31eee0da2586fd533230e66a4d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24b306ed4e73450da06e3eb3e4874688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb55dd2d29c15368bb69c1b35cb87811 |
publicationDate |
1994-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0618807-A1 |
titleOfInvention |
A stabilized pharmaceutical formulation comprising growth hormone and histidine |
abstract |
Pharmaceutical preparation comprising a somatotropin and histidine or a histidine derivative as an additive or a buffer substance. The preparation has a very high stability to deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows it to be stored and transported in a lyophilized state or in the form of a dissolved or redissolved preparation at room temperature. The crystallization of somatotropin in the presence of histidine or a derivative thereof causes an increase in the production of crystals having a higher purity than that of the crystals obtained according to known methods. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0787497-A2 |
priorityDate |
1991-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |