abstract |
Disclosed herein are peptide derivatives of the formula A-B-D-NHCH{CH₂C(O)R¹}C(O)-NHCH{CR²(R³)-COOH}C(O)-E wherein A is a lower alkanoyl bearing two substituents, each substituent selected independently from phenyl or a monosubstituted phenyl wherein the monosubstituent is alkyl, halo, hydroxy or alkoxy; B is a N-methyl amino acid residue; D is an amino acid residue; R¹ is alkyl, cycloalkyl, a monosubstituted amino or a disubstituted amino; R² is hydrogen or alkyl and R³ is alkyl, or R² and R³ are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections. |