| abstract |
The invention relates to a new, advantageous process for the production of liposomes for the inclusion of water-soluble or hydrophilic substances or mixtures of substances, which, in comparison with known processes, has the surprising advantage of increasing the proportion of substances or mixtures of substances actually included and, in pharmaceutical use, the advantage of sterile working conditions offers.n n n A mixture consisting of at least one phospholipid and customary lipophilic excipients is exposed to a mobile carrier phase consisting of carbon dioxide and a polar organic solvent (modifier) under supercritical pressure and temperature conditions, the compressed mixed phase is released to normal pressure and into an aqueous phase containing one in liposomes transferred to encapsulating substance with water-soluble or hydrophilic properties. |