| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5d8a3b3b3faac2562bcdcd68af92186 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-801
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-906
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-915
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G03C2001-0471 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1658
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate |
1992-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6fde691f9a5f63e7e1b0aff6ffb81f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b06538195f2fcb38c87b3ef4a664e558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3006cfeed40c30057369ecd20a975620
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf6687b4aee1c4fdcaf2e92363bbe82a |
| publicationDate |
1994-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0615445-A1 |
| titleOfInvention |
NANOSOL FOR USE IN PHARMACY AND ITS PREPARATION PROCESS. |
| abstract |
Nanosols make it possible to stabilize colloidally dispersed solutions of poorly water-soluble active substances with gelatin or its derivatives, by regulating the iso-ionic point (IIP, equivalent to a neutral charge) of gelatin and particles of the superficially charged active substance so that they coincide partially or entirely. In order to neutralize the charge of the system consisting of particles of active substance and gelatin, the surface charge of the particles is compensated by imparting a corresponding contrary charge to the gelatin molecules. To this end, a determined charge of the gelatin molecules is adjusted in relation to their isoelectric point (IEP) and the pH value of the solution. By thus stabilizing the almost monodisperse state generated, the Ostwald ripening of the colloidal particles of the sparingly soluble active substance is greatly reduced. It is thus possible to obtain a form which can be used in pharmacy having new properties, containing inorganic and organic compounds which are generally not very soluble in water, in particular medicinal substances with problematic bioavailability. Among the preferred drugs are glibenclamide and derivatives of 3-indolylacetic acid, for example indomethacin or acemetacin. The invention also relates to processes for the preparation of these nanosols. |
| priorityDate |
1991-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |