http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0614375-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82b460ae2c0d553a2db7abd984e85631 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2881 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1992-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41079e9df9c74a6e5c5ad12d52f63801 |
| publicationDate | 1994-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0614375-A1 |
| titleOfInvention | Process for the preparation of transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
| abstract | The present invention relates to a method of administering a diagnostic or neuropharmaceutical agent across the aqueous blood-humor barrier to the brain of a host. The method includes administering to the host a therapeutically effective amount of a diagnostic or neuropharmaceutical-antibody conjugate in which the antibody reacts with a transferin receptor and this antibody is a chimera between the variable region of an animal source and the constant region of a different animal source. Other aspects of this invention describe a delivery system comprising an antibody reactive to a transferin receptor linked to a neuropharmaceutical or diagnostic agent and methods of treating a host having a disease associated with a neurological disorder. In embodiments of the present invention, the antibody that reacts to a transferin receptor is a chimeric antibody. This antibody consists of a variable region, reacting by immunology with the transferin receptor, which is brought from an animal source and a constant region which is derived from an animal source other than that which constituted the variable region. The chimeric antibodies of this invention can exist either in the form of isolated entities or in the form of conjugates with a neuropharmaceutical agent to cross the aqueous blood-humor barrier. In the latter mode, the conjugate of neuropharmaceutical agent-chimeric antibody forms a delivery system for administering the neuropharmaceutical agent across the aqueous blood-humor barrier. |
| priorityDate | 1991-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1226.