http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0614367-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aee32ee4d927c3464c11ae4c41d0b557 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7008 |
| filingDate | 1992-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a70d22e83aaf7aa2f66778a6a01755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4664be1985d8422281fc035bc20940de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce8afcbf57431e2457d834fad016ecd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b767c3a013f98b569a438a10d587177 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_400076e00e3173cb91ba1ff8171f0da8 |
| publicationDate | 1994-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0614367-A1 |
| titleOfInvention | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| abstract | The invention relates to simple lactose or lactosamine-like compounds serving as ligands for endothelial leukocyte adhesion molecule-1 (LAM-1) and related receptors. These compounds have the formula (I) in which each R1 independently represents H or lower alkyl (1-4C); R2 represents H, lower alkyl (1-4C), arylalkyl or one or more additional saccharide residues; R3 and R4 each independently represents H, (1-6C) alkyl, aryl or R3 and R4, together, form a five or six membered ring optionally containing a heteroatom selected from the group consisting of O, S and NR1; wherein said five or six element ring can also be substituted by one or more substituents chosen from the group consisting of (CHOR1) mH in which m represents 1 to 4, OR1, OOCR1, NR12, NHCOR1 and SR1; Y represents H, OR1, OOCR1, NR12, NCOR1 or SR1; and X represents -CHR5 (CHOR1) 2CHR6OR1 where R5 and R6 each independently represent H, lower (1-4C) alkyl optionally substituted by one or more F, or results in a five or six element ring optionally containing a heteroatom selected from the group consisting of O, S and NR1; said ring has five or six elements optionally substituted by a substituent chosen from the group consisting of R1, CH2OR1, OR1, OOCR1, NR12, NHCOR1, SR1 and F; or X represents benzoyl or naphthoyl comprising one to three hydroxyl substituents, provided that if X represents a hexose type substituent, R3 and R4 cannot together produce a hexose type substituent. These compounds are useful in the treatment of conditions characterized by excessive inflammation. |
| priorityDate | 1991-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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