| abstract |
Mammals and transgenic birds showing no susceptibility to spongiform encephalopathies (eg diseases caused by prions or scrapie-like), due to the absence of endogenous functional prions ("PrP"). More particularly, DNA targeting molecules are intended to specifically disrupt PrP genes by homologous recombination in transfected animal cells, cultured cells transformed using said DNA targeting molecules, and animals derived from these transformed cells and their transgenic progeny. |