| abstract |
The invention relates to polyionic cyclodextrin derivatives and methods for preparing these derivatives, in which a polyionic cyclodextrin derivative is combined with a growth factor, such as preferably a heparin binding growth factor. These compositions are characterized by low solubility and are applied directly to the site of the lesion. Thanks to their low solubility, these compositions remain in place at the point of application and slowly release the growth factor. Alternatively, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb the growth factor present in the body at the site of the lesion to prevent overstimulation of the growth factor. lesion reaction. |