| abstract |
The invention relates to substantially pure hetero-bicyclic alcohol enantiomers of the formula I, III, and IV <CHEM> wherein X is O, S, NH, N-(C1-C4)alkyl or CH2; Y1, Y2 and Y3 are each independently hydrogen or substituents selected from halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4-haloalkyl, nitro and cyano; the NO2 substituent is attached to the bicyclic ring system in the 5- or 7-position; and the C*-atom has either the R configuration. The invention also relates to the use of said enantiomers for the preparation of a pharmacologically active piperazine derivative. |