| abstract |
Compounds corresponding to formula (I), in which X represents either (a) a phenyl group optionally substituted by 1 or 2 substituents selected, independently of one another, from halo, CF3, C1-C4 alkyl, C1 alkoxy -C4 and hydroxy; or (b) a thienyl group; and X corresponds to the formula (Ya) or (Yb), in which A and B are 0, 1, or 2, D and E are 0 or 1, F is between 0 and 3, and D + E + F = from 1 to 3, Z is 0, 1 or 2, R1 and R1 represent H or alkyl or form a ring, and R3 represents C1-C4 alkyl, C3-C6 cycloalkyl, or optionally substituted phenyl or benzyl. These compounds are anti-muscarinic bronchodilators used in the treatment of chronic obstructive pulmonary disease or asthma. |