| abstract |
Compounds of formula (I) where X represents (a), (b), where L represents N or CRc where Rc represents hydrogen, alkoxy, halo, alkyl or cyano; Q represents NR1, CH2, O or S; Ra represents hydrogen, halo, alkyl, amino, nitro or alkoxy; Rb represents hydrogen, halo, alkyl or alkoxy; R1 represents hydrogen, alkyl, alkenyl, aralkyl, alkanoyl, or alkanoylalkyl; R2 represents alkoxy; and R3 represents hydrogen, chloro or fluoro; R4 represents hydrogen, alkyl, amino optionally substituted by alkyl, halo, hydroxy or alkoxy; R5 represents hydrogen, halo, alkyl, alkoxy, nitro, amino or alkylthio; R6 represents hydrogen, halo, alkyl, alkoxy or amino; n represents 0, 1, 2, 3 or 4; p and m are indifferently 0, 1 or 2; and Rq represents hydrogen or alkyl. The compounds which are the subject of the present invention are antagonists of the 5-HT4 receptor and are generally considered to be usable in the treatment or prophylaxis of gastrointestinal and cardiovascular disorders and those affecting the central nervous system. |