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filingDate 1993-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef036cbc096caa54ce6c4c368e8f4288
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publicationDate 1999-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0601508-B1
titleOfInvention Liquid-suspension controlled-release pharmaceutical composition
abstract Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coatings of polymeric hydrophilic and hydrophobic materials, the first applied of said coatings imparting controlled-release properties to said naproxen according to a predetermined release profile; and (c) a liquid administration vehicle. This composition enables the oral administration of naproxen as a single daily dose and the adjustment of the dosage to a patient's requirements, thus aiding oral intake and minimizing the drug's typical side effects.
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priorityDate 1992-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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