| abstract |
Prozasin is formulated in solution with a composition improving penetration through the skin and comprising a compound containing sulfhydril, a fatty acid ester and a polar solvent for transdermal administration in order to treat hypertension or prostatic hypertrophy benign. The formulation is used in the form of an adhesive tablet (10) applied to the skin and comprising: (a) an impermeable support layer (11), (b) a reservoir (12) containing the prazosin solution, (c ) a porous support element (13) which retains the solution but is not a barrier to the penetration of the solution, a peripheral adhesive layer (14) making it possible to fix the adhesive patch on the skin and a detachable layer of lining ( 15). |