| abstract |
The invention relates to hybrid citokynes containing four helical regions, each of which is derived from a corresponding alpha-helical region in the leukemia inhibiting factor (FIL), the granulocyte colony stimulating factor (FSC-G). , interleukin-6 (IL-6) or oncostatin-M (OSM). These hybrid cytokines may further contain link regions also derived from corresponding link regions in these factors. Hybrid cytokines offer a unique spectrum of activity useful for the treatment of conditions for which natural cytokines are useful or for the treatment of conditions characterized by an excess of natural cytokines. |