| abstract |
Pharmaceutical compounds of the formulan n R¹ is phenyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl and heteroaryl groups being optionally substituted, or R¹ is furanyl optionally substituted with C₁₋₄ alkyl; nR² is nitrile, carboxy, -COOR⁴ where R⁴ is an ester group, -CONR⁵R⁶ where R⁵ and R⁶ are each hydrogen or C₁₋₄ alkyl, or R⁷SO₂- where R⁷ is C₁₋₄ alkyl or optionally substituted phenyl; nR³ is -NR⁸R⁹, -NHCOR⁸, -N(COR⁸)₂, -N=CHOR⁸ where R⁸ and R⁹ are each hydrogen or C₁₋₄ alkyl, or -NHSO₂R¹⁰ where R¹⁰ is C₁₋₄ alkyl or optionally substituted phenyl; orn n where X is C₂₋₄ alkylene; and nthe groupn n represents a pyridine ring fused to the benzopyran nucleus; nand salts thereof. |