| abstract |
The present patent application discloses compounds of the formulan n wherein nR¹ is C₁₋₁₀-alkyl which may be branched; C₁₋₁₀-unsaturated alkyl; or CHR'''n n wherein R''' is H orn n R² is phenyl which may be substituted one or more times with halogen, CF₃, C₁₋₆-alkoxy, NO₂, CO₂-C₁₋₆-alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF₃, C₁₋₆-alkoxy, NO₂, CO₂-C₁₋₆-alkyl, methyl; pyridyl; or cyclohexyl; nR³ phenyl which may be substituted one or more times with halogen, CF₃, C₁₋₆-alkoxy, NO₂, CO₂-C₁₋₆-alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF₃, C₁₋₆-alkoxy, NO₂, CO₂-C₁₋₆-alkyl, methyl; pyridyl; C₁₋₆ unsaturated alkyl; furanyl; nR⁴ is H, C₁₋₆-alkyl, or benzyl; norn n together formn n R⁵ is H, or C₁₋₆-alkyl; nR' and R'' are each hydrogen or together form an extra benzo ring; nand wherein the dotted line represents an optional extra bond between the two carbon atoms designated α and β, or a pharmaceutically-acceptable addition salt thereof. n The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells. |