| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_746d8243701ae4271b74368451625bee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
| filingDate |
1990-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddd7508bbefd02141644946d7956dbf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20aec3626f62fbafbaeea5ee6c81e552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a2ca18d40e7aa5ebfc36a583b88c35a |
| publicationDate |
1994-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0598116-A1 |
| titleOfInvention |
Fat emulsion |
| abstract |
A fat emulsion developed to solve the problems of polyene antifungal antibiotics that they have such a severe toxicity as to limit the administration range thereof by suitably designing the administration form, thereby reducing the hemolytic toxicity and nephrotoxicity and facilitating the migration of a drug toward infected parts without adversely affecting the pharmacological action (antifungal action) on a molecular level. The emulsion comprises 0.005 to 5 % of a polyene antifungal antibiotic, 0.5 to 30 % of a simple lipid, and a phospholipid in an amount 0.15 to 2 times as large as that of the simple lipid, wherein the relative proportion of each ingredient is controlled to give a fine microemulsion of a mean particle diameter of at least 10 nm up to 100 nm. This emulsion can remarkably enhance the efficacy of polyene antifungal antibiotics such as Amphotericin B and is very useful for the development of medicines. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9932152-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2511028-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6346272-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6399624-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6436425-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19825856-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9932152-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6136334-A |
| priorityDate |
1989-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |