http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0596057-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 1993-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4924d0b4b1b1316ad04d443beb0a51a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e357a46f26745a7da95a25e999c433e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_378e29a39f295d4c82fedf9c788c5eca |
| publicationDate | 1994-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0596057-A1 |
| titleOfInvention | Quinuclidine derivatives as squalene synthase inhibitors |
| abstract | This invention relates to compounds of formula I and their pharmaceutically acceptable salts in which R1 represents hydrogen or hydroxy; R2 represents hydrogen; or else R1 and R2 are combined so that CR1-CR2 represents a double bond; X is selected from -CH2CH2-, -CH = CH-, -C = C-, -CH2O-, -OCH2-, -CH2NH-, -NHCH2, -CH2CO-, -COH2-, -NHCO-, -CONH- , -CH2S, -SCH2, in which the sulfur atom located in the last two groups can optionally carry one or two oxygen atoms; Ar1 represents a phenylene fraction; Ar2 represents phenyl; Ar1 and / or Ar2 can be optionally unsubstituted or independently substituted by one or more substituents selected from halogen, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, d-alkylamino, N-alkylcarbamoyl, N, N-di-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkyl, alkanoyl, methylenedioxy and alkanoylamino. These compounds are inhibitors of squalene synthase and therefore they are useful for treating medical conditions in which lowering of cholesterol is desirable, such as hypercholesterolemia and atherosclerosis. Methods of preparing these derivatives, pharmaceutical compositions containing them and their use in medicine are also described. |
| priorityDate | 1992-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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