| abstract |
Soluble fusion molecule containing the extracellular binding region of leukocyte receptors are described which are capable of binding to extracellular matrix associated proteins. The described lymphocyte to ligand proteins include soluble fusion molecules of 4-1BB, CD27, CD30, FAS, TNF receptor and CD40. A method of modulating leukocyte function is described in which a soluble lymphocyte between leukocyte receptors and the extracellular matrix associated protein of the target tissue. |