abstract |
New dialkyl (dialkoxyphosphinyl) methyl phosphates of formula (IV) used as anti-inflammatory and anti-arthritic agents are described. The compounds are synthesized from the reaction of tetraethyl oxyranylidenebisphosphonate and unsubstituted or alkylated amines. Representative compounds include diethyl ester of 2- (benzylamino) -1- (diethoxyphosphinyl)) ethyl phosphonic acid, diethyl ester of 1- (diethoxyphosphinyl) -2- [2 '- (1', 2 ', 3', 4'-tetrahydro) napthylamino] ethyl phosphonic, the diethyl ester of 2- (3-fluorobenzylamino) -1- (diethoxyphosphinyl) ethyl phosphonic, and 5,5-dimethyl-2- [2- (3-fluorobenzyl) amino-1 - [(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl) oxy] ethyl] -1,3,2-dioxaphosphorinane P, 2-dioxide. |