| abstract |
A triphenylalkene derivative represented by general formula (1), a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical composition thereof having a tumor inhibitory action and an osteoporosis curing activity. In general formula (1) R₁ represents a group selected among those represented by formulae (2), (3) and (4); R₆ and R₇ represent each hydrogen, alkyl or cycloalkyl, or R₆ and R₇ together form a heterocyclic group with the adjacent nitrogen atom, provided that R₆ and R₇ should not be hydrogen atoms at the same time; R₈ represents hydrogen or alkylcarbonyl; R₂ represents alkyl or cycloalkyl; R₃ represents phenyl or 3,4-methylenedioxyphenyl, provided that when R₃ represents phenyl, the case where R₁ represents a group of formula (4) is excluded; R₄ represents hydrogen, hydroxyl, R₉C(O)O-, R₁₀OCH₂O-, -OPO(OH)₂ or CH = NOR₁₁; R₉ represents alkyl; R₁₀ represents alkyl or alkylcarbonyl; R₅ represents hydrogen or CH = NOR₁₁; and R₁₁ represents hydrogen, alkyl or substituted alkyl. |