| abstract |
Compositions and methods utilizing TGF-β and demineralized bone matrix are described that are capable of inducing the formation of useful, non-resorptive bone. Bone formation is stimulated by the synergistic activity of a TGF-β molecule, such as TGF-β1 or TGF-5β, with a HCl-treated demineralized bone matrix. Normal, hard non-resorptive bone development is stimulated and can be utilized in the treatment of fractures, skeletal defects, surgical repairs and skeletal reconstructions, such as in maxillofacial reconstructions. |