| abstract |
New bicyclic amides of formula (I) in which Ar2 and Ar2 have phenyl, phenyl substituted by R2, heteroaryl or heteroaryl substituted by R2, R2 being 1 to 3 constituents independently selected from the group formed of halo, hydroxy, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino and lower dialkylamino; X, Y, and Z are -CH2-, -CH (alkyl) -, -C (alkyl) 2-, -NH-, -N (alkyl) -, -O- or -SOr-, r being 0, 1 , or 2 and m, n and p being 0 or 1; R1 is an alkyl chain of 1 to 25 carbon atoms, an alkyl chain substituted by one or more heteroaryl or phenyl groups optionally substituted, an alkyl chain -0-, SO0-, phenylene, phenylene substituted by R2, heteroarylene or heteroarylene groups substituted by R2, an interrupted alkyl chain substituted by one or more phenyl or heteroaryl groups optionally substituted, an alkyl chain of 4 to 25 carbon atoms, interrupted by one or more groups -NH-, -C (O) - or -N (lower alkyl) -, an interrupted alkyl chain of 4 to 25 carbon atoms substituted by one or more phenyl groups, phenyl substituted by R2, heteroaryl or heteroaryl substituted by R2, a diphenylamino group, an amino diphenyl group substituted by R2, diheteroarylamino group or an amino di-heteroaryl group substituted by R2, or a pharmaceutically acceptable salt of said amides, useful in the treatment of atherosclerosis. |