| abstract |
Compounds having an aldose reductase inhibiting activity and corresponding to formula (I), in which X represents CH2, CH2CH2, -CHCH3 or (a); Y = O or S; R1 represents a phenyl group, benzothiazol-2-yl, benzoxazol-2-yl, benzofuran-2-yl, benzothiophen-2-yl, thiazopyridin-2-yl, oxazolopyridin-2-yl, 3-phenyl-1,2, 4-oxadiazol-5-yl and optionally substituted 5-phenyl-1,2,4-oxadiazol-3-yl, said substituted groups being substituted by at least one and preferably two substituents selected independently of one another from fluorine, chlorine, bromine, methyl and trifluoromethyl; R2 and R3 are selected, independently of each other, from hydrogen, fluorine, chlorine, bromine (C1-4) alkyl, methylalkylthio (C1-4), alkoxy (C1-4) and trifluoromethyl, or jointly form with the carbon atoms to which they are linked a group W, where W represents (b) or (c), where p is 1 or 2 and U1 and U2 independently represent CH2, O or S provided that U1 and U2 do not represent both O or S; R4 represents hygrogenic or a drug precursor group; or their pharmaceutically acceptable salt. |