| abstract |
The rapidity of viral resistance developed during treatment with antiviral nucleoside analogues is reduced by administering double-stranded RNA during the first stage of treatment of the infection or during later stages, when the viral genetic mutation has appeared, in order to restore the susceptibility of the virus to antiviral agents which would otherwise be ineffective. Delay and / or decrease in the appearance of retroviruses resistant to nucleoside analogs, in particular HIV, is achieved by means of poorly paired RNAs, in particular in peripheral mononuclear blood cells, in particular CD4 lymphocytes. |