| abstract |
The present invention relates to carbapenems and provides a compound of the formula (I)n nwherein :n R 1 is i-hydroxyethyl, 1-fluoroethyl or hydroxymethyl ; R 2 is hydrogen or C 1-4 alkyl ; R 3 is hydrogen or C 1-4 alkyl ; P' is of the formula : n nand one or two of A,B,C,D,E,F,G and H, are nitrogen and the remainder are CH ; and P is bonded to the nitrogen of the linking carbamoyl group by a carbon atom, in either ring, is substituted by the carboxy group on a carbon atom, in either ring, and is optionally further substituted, by up to three substitutents, on a carbon atom, in either ring ; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described. |