| abstract |
The extract based on modified bacterial proteins comprises a mixture of acidic bacterial polyanions having a molecular weight of 10,000 to 1,000,000 and an isoelectric point between 2.5 and 5.5, and in which the weight sum constituent amino acids represents at least 50% of said extract. The preparation of this protein extract comprises the culture of bacteria in an aqueous medium, then the alkaline extraction of this bacterial suspension and the purification of the protein extract. The alkaline extraction is carried out in the presence of a dilute aqueous source of OH- ions and at a stable pH of between 11 and 13, the drop in this pH during said extraction not being greater than 0.4. The protein extract thus obtained can be used as an active ingredient in a pharmaceutical composition. |