| abstract |
Disclosed are compounds of formulan n wherein n R is hydrogen, hydroxy, esterified hydroxy or etherified hydroxy; n R₁ is hydrogen, halogen, trifluoromethyl or lower alkyl; n R₂ is hydrogen, halogen, trifluoromethyl or lower alkyl; n R₃ is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; or n R₃ is the radicaln n wherein R₈ is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkyl-lower alkyl; R₉ is hydroxy or acyloxy; R₁₀ represents hydrogen or lower alkyl; or R₉ and R₁₀ together represent oxo; n R₄ is hydrogen, halogen, trifluoromethyl or lower alkyl; n X is -NR₇; n W is O or S; n R₅ and R₆ together represent oxo; n R₇ represents hydrogen or lower alkyl; n Z represents carboxyl, carboxyl derivatized as a pharmaceutically acceptable ester or as a pharmaceutically acceptable amide; and pharmaceutically acceptable salts thereof; which are useful as hypocholesteremic agents. |