http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0580210-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-28 |
| filingDate | 1993-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21165540c65cb63eaa4e33ae3416f307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07627703f7f5d8980d1d8e2817db017a |
| publicationDate | 1996-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0580210-B1 |
| titleOfInvention | Process for the preparation of optically active methionine amide |
| abstract | The invention relates to a process for the preparation of optically active methionine amide according to which a mixture of D- and L-methionine amide or the Schiff bases thereof is at least partly converted, optionally in the presence of 0.5-4 equivalents of an aldehyde, relative to the amount of methionine amide, and water, in the presence of an organic solvent, using less than 1.2 equivalents of L- or D-mandelic acid, respectively, relative to the amount of D- or L-methionine amide, respectively, or the Schiff bases thereof, present in the mixture of D- and L-methionine amide or the Schiff bases thereof, into a salt of methionine amide and mandelic acid, a portion consisting substantially of one of the diastereoisomers of said salt is separated from the reaction mixture obtained and the salt is converted into the optically active methionine amide in a manner known per se. A high degree of optical purity is obtained. This process can be advantageously combined with a preparation of D,L-methionine amide from D,L-methionine nitrile by returning the residual methionine amide obtained after separation of the diastereomeric salt and recovery of the mandelic acid to the preparation of D,L-methionine amide where racemisation of the recycled methionine amide takes place in situ. In this manner a high overall efficiency is obtained in spite of a relatively low efficiency of conversion into the diastereoisomeric salt, relative to the amount of D- and L-methionine amide, or the Schiff bases thereof, used. |
| priorityDate | 1992-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.