| abstract |
The invention relates to heterocyclic compounds represented by the formula (I) which are used for the treatment of AIDS and AIDS-associated syndrome. These compounds are generally synthesized by following the reactions and conditions used to produce the Reissert compounds. The compounds of formula (I) are 1,2-dihydroquinolines, 1,4-dihydroquinolines, 1,2,3,4-tetrahydroquinolines, 1,2-dihydroquinazolines and 1,2-dihydroquinoxalines. Typical compounds are 1- (4-bromobenzoyl) -2-cyano-1,2-dihydroquinoline, 1- (4-chlorobenzoyl) -2-cyano-5-fluoro-1,2-dihydroquinoline, 1- (4-chlorobenzoyl ) -2-cyano-6-fluoro-1,4-dihydroquinoline, 1- (4-chlorobenzoyl) -2-cyano-1,2,3,4-tetrahydroquinoline, 1- (4-chlorobenzoyl) -2-carboximidamide- 8-fluoro-1,2-dihydroxyquinoline, 1- (4-chlorobenzoyl) -2-cyano-1,4-dihydroquinoxaline, 1-E- (3- (4-chlorophenyl) -1-oxo-2-propenyl) - 2-cyano-1,2-dihydroquinoline and 1-E- (3- (4-chlorophenyl) -1-oxo-2-propenyl) -2-carboximidamide-1,2-dihydroquinoline. The invention also describes a method of treating AIDS or the syndrome associated with AIDS using an effective amount of one of these compounds. |