| abstract |
A fused benzeneoxyacetic acid derivative of the formula:n n whereinn n isn (i)n (ii)n (iii)n or (iv)n n A is (i)n or (ii) R¹ is hydrogen or C₁₋₄ alkyl; R² is hydrogen, C₁₋₆ alkyl or phenyl; R³ is (i) C₁₋₁₅ alkyl, (ii) C₁₋₈ alkyl substituted by one or two of benzene, C₄₋₇ cycloalkane or 4-7 ring-membered monocyclic ring which contains one nitrogen atom or (iii) C₁₀₋₁₅ condensed tricyclic ring; e is 3-5; f is 1-3; p is 0-4; q is 0-2; s is 0-3 With the proviso that, ring(s) in R³ may be substituted by one to three of C₁₋₄ alkyl, ₁₋₄ alkoxy, halogen atom, nitro or trihalomethyl. And, when D -- ¯ B is the formula (iii) or (iv), -(CH2)p- or =CH-(CH2)s- is attached at the position of a or b on the ring. nand non-toxic salts thereof possess an antagonistic activity on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension. |