http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0575526-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea72e2de3c0219165474e54e9842d16 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 |
| filingDate | 1992-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56335989e4bf37a4e3f291836ef5d865 |
| publicationDate | 1993-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0575526-A1 |
| titleOfInvention | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES |
| abstract | Compound of formula (I) in which R represents C1-C10 alkyl; phenyl or C7-C10 aralkyl; C2-C10 alkyl substituted with 1 or 2 substituents selected from the group consisting of OR1 and -NR2R3; C2-C10 alkyl interrupted by 1 or 2 oxygen atoms or by an element chosen from the group consisting of -NR4-, cis -CH = CH-, trans -CH = CH- and -C = C-, and optionally substituted with one or two hydroxy (OH) or -NR2R3 groups; and wherein R1 is selected from the group consisting of hydrogen C1-C6 alkyl, phenyl, C7-C10 aralkyl, -CHO, COR5-, -COOR5, -S (O2) R5 and C2-C6 alkyl optionally substituted by -NR2R3; R2 and R3 are the same or different and they are chosen from the group consisting of hydrogen, C1-C10 alkyl, C7-C10 aralkyl, phenyl, C2-C10 alkyl substituted by one or two hydroxy (OH) groups, -CHO-, - COR5, -COOR5, and S (O2) R5, R2 and R3, taken together with the nitrogen atom to which they are attached, form an ethyleneimine ring or an aromatic or non-aromatic heterocyclic ring with 5 or 6 elements optionally containing a another heteroatom chosen from the group consisting of sulfur, oxygen and nitrogen, R2 represents H and R3 represents -C (= NH) NH2 or R2 represents -C (= NH) NH2 and R3 represents H; R4 is selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 hydroxyalkyl, C2-C10 alkyl substituted by -NR2R3, C7-C10 aralkyl, phenyl -COR5, -COOR5 and -S (O2) R5; R5 is chosen from the group consisting of C1-C10 alkyl, C7-C10 aralkyl, alpha-, beta-, or gamma-naphthyl, phenyl, o-, m-, or b-tolyl used as free bases, as well as their salts with pharmaceutically acceptable acids which have been found to exhibit cytostatic and anti-tumor activity. |
| priorityDate | 1991-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 191.