Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_386cb7617dc58288fcea755bb041387a |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
filingDate |
1991-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2002-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b341a3a0c214084ba30b41444ec31ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce5bc97bd7b84422cccded962e8906a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_927a655ec042fbdb7d3aa7a0095ff511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a16c0972032598744f791318b9fb31e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2eea473f15371f31c3e51c0682e331c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d00c73b9c695dd519c35ab067fc2d22e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e955bcd74cadd29ca3bc23042d2ae8ad |
publicationDate |
2002-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0574391-B1 |
titleOfInvention |
Antibodies against the urokinase receptor and their use |
abstract |
The present invention discloses the use of a monoclonal or polyclonal antibody directed against urokinase plansminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. The antibodies react with free u-PAR or with complexes between u-PA and u-PAR and are able to inhibit the binding of pro-u-PA and active u-PA to u-PAR and thereby inhibit cell surface plasminogen activation. Thus, methods for preventing or counteracting proteolytic activity in a mammal is disclosed. Furthermore are screening methods for selecting substances suitable for inhibiting u-PA/u-PAR interactions disclosed. The substances identified by the screening method and the antibodies directed against u-PAR can be used for preventing or counteracting localized proteolytical activity in a mammal, such as for inhibiting the invasion and/or metastasis in a mammal. |
priorityDate |
1990-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |